Essential Formulas Announces Publication of Scientific Study Demonstrating the Significant Anti-Fatigue Effect of Dr. Ohhira’s Probiotics

Dallas, Tx- October 19, 2022 – Essential Formulas Incorporated is proud to announce the publication of the original research study, “The Anti-Fatigue Effect of Dr. Ohhira’s Probiotics (OM-X)” in the Journal of Functional Foods, October 2022, 105228.

Researched and authored by esteemed scientists Takeshi Kaneko, Akinobu Miyata, and Muneaki Takahata, the randomized, placebo-controlled, double-blind, comparative human study was designed to the same standards used in pharmaceutical drug trials.

This was a 12-week, double-blind, placebo-controlled trial. Forty healthy men and women between the ages of 40-59 were randomly divided into two groups. One group took three capsules of Dr. Ohhira’s Probiotics once daily for 12 weeks, and the other group took three capsules of an identical-looking placebo for 12 weeks. Only healthy individuals participated in the study, as people with significant health problems were excluded.

The following two independent methods were used to measure levels of fatigue in this clinical trial:

  1. Visual Analog Scale (VAS): This scale consists of a horizontal line 10 centimeters (3.94 inches) long. Participants are asked to place an ‘x’ on the line representing their fatigue level over the past seven days (left side = low fatigue, right side = high fatigue). The placement of the ‘x’ is then converted into a numerical score. A higher score corresponds with higher fatigue.
  2. Chalder Fatigue Scale (CFS): This questionnaire consists of 14 questions relating to different aspects of physical and mental fatigue. The rating goes from 1 (no fatigue) to 4 (high level of fatigue). The higher the total score, the higher the overall level of fatigue.

All participants consuming Dr. Ohhira’s Probiotics registered significant reductions in fatigue on both the Visual Analog Scale and the Chalder Fatigue Scale. This finding provides robust scientific validation that taking Dr. Ohhira’s Probiotics (3/day x 12 weeks) lowers fatigue levels and increases energy in healthy adults.

For several years, Dr. Ohhira’s Probiotics have been produced by fermenting many plant-based foods with lactic acid bacteria (LAB). The final product contains over 500 postbiotic metabolites such as antioxidants, short-chain fatty acids, organic acids, vitamins, polyphenols, carotenoids, and more. It is well known that increased levels of free radicals can damage mitochondria. This, in turn, reduces the production of cellular energy (ATP), which results in higher levels of mental and physical exhaustion and fatigue. The antioxidant activity provided by the ingredients in Dr. Ohhira’s Probiotics, especially the antioxidant activity of various postbiotic metabolites and polyphenols, explains the reduced fatigue levels in this recently published human scientific study.

“Over thirty years of supporting science has earned Dr. Ohhira’s Probiotics the respect of scientific, academic, medical, and holistic health communities worldwide,” said William Schoor, President of EFI. “We are proud that this new study is an added component in substantiating the trust and loyalty in this exceptional supplement.”

*For a full copy of the research study, click here.


Celebrating 22 Years of “Proven Probiotic Science,” Essential Formulas Incorporated (EFI) is the sole U.S. distributor of world-renowned microbiologist Dr. Iichiroh Ohhira’s award-winning probiotic supplements and skincare products. Always an innovator, EFI introduced Reg ’Activ® in 2015. Reg’Activ products contain Lactobacillus fermentum ME-3, a unique strain of probiotic bacteria that produces the “Master Antioxidant” glutathione. Essential Formulas is a family-owned and operated company whose mission is to market premium probiotics and other high-quality health-related products in the United States, Canada, and Mexico.

Media Contact:
Kelly Charles/Kc Communications