
A Probiotic Strain that Makes Antioxidants
Discover Lactobacillus fermentum ME-3: Powerful Effects for Cardio, Detox, and Immune System Wellness.*

Reg´Activ® Probiotics: Boost Your Immune Health with ME-3
Strengthen your whole body with Lactobacillus fermentum ME-3! Learn how this beneficial bacterium improves health, backed by science. Discover top strains and expert advice on supporting glutathione levels for immune health.
Probiotic research is fast transforming our understanding of human health. Probiotics in general are invaluable for maintaining good health. We're also learning we need certain strains that produce highly specified health benefits.*
One of these strains is Lactobacillus fermentum ME-3. The startling probiotic breakthrough of ME-3 began in 1995. That's when award-winning microbiologist Marika Mikelsaar, MD, PhD and her team of research scientists isolated the probiotic strain called Lactobacillus fermentum ME-3. This unique strain is able to produce the super antioxidant glutathione. Since then, Dr. Mikelsaar has dedicated herself to researching the numerous benefits of this revolutionary probiotic.*
While ME-3 is a glutathione-producing probiotic, Dr. Ohhira's Probiotics and Reg´Activ® are not rival products. On the contrary, they are extremely synergetic but with differing commitments and capabilities. Dr. Ohhira’s is the leading product to “remodel the digestive tract.”
ME-3 is proven to produce glutathione naturally in the human body. Working as a glutathione-activating agent via three different mechanisms, Reg´Activ® is set to impact the future of preventative and restorative health on a cellular level. The similarity between these groundbreaking formulations is the decades of science backing their validity and health restorative effects.
Why Glutathione is Crucial for Immunity?
Glutathione is essential for cellular health and is known as the "master antioxidant." While crucial for health, direct glutathione supplementation can be challenging due to breakdown during digestion. Foods rich in sulfur, curcumin, vitamin C, selenium, and vitamin E can support the body's natural glutathione production.
Probiotic research highlights the importance of gut health for overall well-being. Reg´Activ® formulas, featuring ME-3, are designed to provide targeted support for various body systems.
Reg´Activ® and the Power of ME-3
Reg´Activ® offers a novel approach to boosting glutathione levels. Its key ingredient, Lactobacillus fermentum ME-3, is a probiotic that works within the gut to maintain healthy glutathione levels. This supports:
- An improved healthy immune system*
- Balanced Cardiovascular health
- Healthy liver function*
Essential Formulas named the brand Reg´Activ®, short for "Active Regeneration," because ME-3 promotes the production and recycling of glutathione, leading to higher levels of active glutathione and stronger immune support.
You need healthy glutathione levels, but it's very hard to supplement it—some research indicates that glutathione breaks down during digestion. That's where ME-3 comes in. You supplement with the probiotic. Then the probiotic gets to work, maintaining healthy glutathione levels inside you! It's a paradigm-changing approach to health. We hope you enjoy learning about this discovery as much as we did.
Lactobacillus fermentum ME-3: A Breakthrough Probiotic
Discovered in 1995 by Dr. Marika Mikelsaar, ME-3 is a unique probiotic strain with distinctive antioxidative properties. It plays a vital role in glutathione synthesis (making), uptake (absorption), and redox turnover (recycling). ME-3 is proven to naturally produce glutathione, working through these three distinct mechanisms to support cellular health.
Reg´Activ® Formulas: Probiotics for Targeted Immune Support
Research increasingly links gut health to numerous aspects of health, particularly the immune system. With 70-80% of immune cells residing in the gut, a healthy microbiome is crucial. Probiotics like ME-3 help stimulate immune cells, balance the immune system, and produce beneficial compounds.
The Gut-Brain-Immune Connection
The gut and brain are interconnected through the gut-brain axis, influencing immune function. Factors like stress, diet, and medications can disrupt the gut microbiome, weakening the immune system. ME-3 probiotics help restore balance and support immune health.
Choosing the Right Probiotics
When selecting a probiotic, consider the following:
- Strain identification
- Ingredient list (avoid unrecognizable chemicals)
- Allergen information (gluten-free, dairy-free)
- Vegan certification
Consult your doctor before starting any new supplement, especially if you have existing health conditions.
Incorporating Probiotics into Your Routine
You can introduce probiotics into your health routine through supplements like Dr. Ohhira’s® and Reg´Activ®, which contain diverse strains, prebiotics, and postbiotics. Fermented foods like yogurt, kimchi, and kombucha are also good sources, but may have inconsistent strain viability.
Reg´Activ® Product Line
Essential Formulas offers four Reg´Activ® products:
- Cardio Wellness: ME-3 with heart-healthy B vitamins, CoQ10, and NAC.
- Detox & Liver Health: ME-3 with selenium, NAC, and milk thistle.
- Immune & Vitality: ME-3 with vitamin D3, vitamin C, and B vitamins.
- Essential ME-3: A concentrated ME-3 formula with a prebiotic base.
Reg´Activ® and Dr. Ohhira’s®: A Complementary Approach
Dr. Ohhira’s® Probiotics provide a foundation for gut health with 13 diverse strains. Reg´Activ®, with its targeted ME-3 formulation, complements Dr. Ohhira’s® by providing specific immune support and other health benefits.
FAQs about Probiotics and Immunity
- Do probiotics prevent illness? Probiotics strengthen the immune system to help your body naturally fight off health challenges.
- How long until probiotics work? Consistency is the key along with better lifestyle choices – improved diet, regular exercise and stress reduction.
Dr. Ohhira’s®: Quality and Effectiveness You Can Trust
Essential Formulas is committed to producing high-quality products, including Reg´Activ® ME-3 formulas, Dr. Ohhira’s® Probiotics, and Dr. Ohhira’s® skincare products, to support your overall well-being.
What's In A Name?
The brand name Reg´Activ® was created from the words "Active Regeneration.” This expresses what occurs when the patented probiotic Lactobacillus fermentum ME-3 remarkably produces and recycles Glutathione, the "Master Antioxidant,” resulting in higher levels of active glutathione functioning in the body for a longer period of time.*