Ross Pelton R.Ph., Ph.D., CCN

Explanation of the Science Behind Reg´Activ® IMMUNE & VITALITY™

By Ross Pelton, RPh, PhD, CCN
Scientific Director, Essential Formulas


Reg’Activ® IMMUNE & VITALITY combines the glutathione-producing probiotic Lactobacillus fermentum ME-3 with Lactobacillus brevis KP08. A novel probiotic strain from Japan, KP08, promotes the balanced production of interferon-, which supports a healthy immune response. This unique probiotic formula provides highly synergistic immune system effects. ReǵActiv IMMUNE & VITALITY also contains essential B vitamins, vitamin C, and a vegan-derived vitamin D to support immune health, balanced metabolism, and promote energy production.

Together, these synergetic ingredients promote a balanced immune response and help maintain energy levels on a cellular level. No other product on the market today approaches immune health in this way.

Is Lactobacillus fermentum ME-3 a probiotic and what is its function in strengthening the immune system?

Lactobacillus fermentum ME-3 is a patented strain of beneficial bacteria that contains a Glutathione-boosting probiotic that is the cornerstone of the entire Reg’Activ line of supplements. ME-3 releases the “Master Antioxidant,” Glutathione, directly into the intestines, bypassing the normal digestive breakdown and ensuring the availability of more Glutathione to the body.

Researchers recognize the significance of Glutathione’s role in cell detoxification and renewal, which helps reinforce the immune system. However, until Reg’Activ, glutathione supplements of the past have been only minimally effective since Glutathione degrades during ingestion. It’s much more effective to take Reg’Activ and allow the process of generating Glutathione within the body.

ME-3 works as a glutathione activator that boosts the production of the antioxidant and helps the body use it more efficiently. Regular use of Reg’Activ products offers the best option for promoting and preserving healthy glutathione levels in the body.

What is Lactobacillus Brevis KP08, and why is it added to the Reg’Activ Immune & Vitality formula?

Lactobacillus brevis KP08 is a strain of probiotic bacteria that provides unique immune system-supporting properties. Studies report that KP08 promotes interferon-alpha production and the activity of 2-5 synthetase. Both functions are potent activities in the immune system’s handling common day-to-day challenges.

KP08 also supports natural killer cells’ regular activity (NK). Natural killer (NK) cells are an essential part of the body’s frontline immune response—addressing common challenges outside the body and maintaining healthy cellular apoptosis within the body.*

As of 2016 there are 15 publications on the various functions and benefits of KP08 (KB290) that appear in the PubMed database. When searching for information about this species on your own, it is helpful to know that the official name of Lactobacillus Brevis KP08 is “Lactobacillus Brevis subspecies coagulans.” It is also sometimes referred to as KB290. Sometimes a bacterial strain will have more than one commercial name. Both KP08 and KB290 refer to Lactobacillus Brevis subspecies coagulans.

KP08 was discovered in Japan and is quite popular due to its proven immune system-supporting properties. Reg’Activ Immune & Vitality formula is the first probiotic product outside of Japan to utilize KP08.*

Why does Reg’Activ Immune & Vitality contain only 4 billion ME-3 bacteria per daily dose (2 capsules), whereas Cardio Wellness and Detox & Liver Health provide 6 billion ME-3 bacteria per dose?

The lower ME-3 dosage in the Immune & Vitality formula “makes room” for the added KP08 strain. It was determined this was appropriate for the Immune & Vitality formula since KP08 adds powerful synergistic support for immune system activity.*